DNA ligases seal 5′-PO4 and 3′-OH polynucleotide finishes through 3 nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic condition syndromes. Crystal buildings of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated how https://jackr234gcv0.wikigdia.com/user