Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON state�? On ligation of Wnts for their receptors composed of frizzled proteins and LRP5/six, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates in to the nucleus and binds to TCF/LEF transcription components https://finnbmxen.blogoscience.com/34788378/how-much-you-need-to-expect-you-ll-pay-for-a-good-xmu-mp-1