Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and expanding the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have identified recurrent mutations in genes regulating tumor mobile-microenvironment interactions, t... https://raelq753raj2.wikidirective.com/user